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Medications that inhibit CYP2D6 activity, for instance paroxetine and quinidine, may well bring about lowered clearance of oxycodone which could lead to an increase in oxycodone plasma concentrations. Concurrent administration of quinidine resulted in a rise in oxycodone Cmax by 11%, AUC by 13%, and t½ elim.They informed the investigators that the
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